This book cover basic issues concerning the nature of the worldwide health problem posed by cigarette smoking and explore the psychoydnamics of cigarette addiction. The basic pharmacology and biochemistry of nicotine and its effect on the brain are reviewed here. The roles of different nicotine receptor subtypes and other neurotransmitter systems are discussed. Chapters analyse data on genetic factors in the susceptibility to nicotine addiction. In Western countries, cigarette smoking as an adult has a heritability of 30-50% and candidate genes have been identified that may contribute to addiction susceptibility.<br /><br />The book also covers various approaches to therapy. Structured behavioural support programmes aid cessation attempts as do a number of pharmacotherapies, most notably nicotine replacement treatments and bupropion. A continuing theme in the discussions throughout the book is how best to treat nicotine addiction, given that many smokers would like to stop smoking but are unable to do so because of their addiction. (2006. 300 p.)
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